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Transcriptomic meta-analysis identifies dysregulated pathways and potential therapeutic targets in Vestibular Schwannoma

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  • Ebrar Altınalan
  • Aleksandra Panina
  • Robert Fredriksson
  • Ayse Arzu Şakul
  • Helgi B Schiöth

Abstract

Vestibular schwannoma (VS) is a benign Schwann cell–derived tumor that frequently causes progressive hearing loss and vestibulocochlear dysfunction, substantially impacting quality of life. The molecular mechanisms underlying VS pathobiology remain poorly defined, and reliable biomarkers or targeted therapies are lacking. This study aimed to delineate the molecular landscape of VS through a transcriptome-wide meta-analysis. We performed a genome-wide random-effects meta-analysis of four independent Affymetrix microarray datasets from the Gene Expression Omnibus (GEO) database. Differential expression analyses were conducted with and without covariate adjustment. Gene Ontology enrichment and DrugBank-based drug–gene interaction analyses were subsequently applied to characterize biological pathways and assess translational potential. Across the meta-analysis, more than 3,200 differentially expressed genes were identified in the covariate-free model. After applying a more stringent threshold (|metaLFC| > 1 and FDR

Suggested Citation

  • Ebrar Altınalan & Aleksandra Panina & Robert Fredriksson & Ayse Arzu Şakul & Helgi B Schiöth, 2026. "Transcriptomic meta-analysis identifies dysregulated pathways and potential therapeutic targets in Vestibular Schwannoma," PLOS ONE, Public Library of Science, vol. 21(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0353343
    DOI: 10.1371/journal.pone.0353343
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