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Favorable association between early initiation of sodium-glucose cotransporter-2 inhibitors and in-hospital prognosis in acute myocardial infarction

Author

Listed:
  • Hung Thanh Quach
  • Anh Thi Kim Nguyen
  • Bao Quoc Dinh
  • Tuan Minh Nguyen
  • Hoang Huy Bui
  • Tuan Ngoc Tran
  • Tien Dung Ho
  • An Le Pham
  • Si Van Nguyen

Abstract

Introduction: Acute myocardial infarction remains a major cause of death and disability worldwide, especially in low- and middle-income countries. Standard early management includes dual antiplatelet therapy, statins, beta-blockers (BB) and renin–angiotensin–aldosterone inhibitors (ACEi/ARB/MRA). Sodium–glucose cotransporter-2 inhibitors (SGLT2i) have been associated with favorable changes in cardiac function in acute myocardial infarction, but their impact on in-hospital mortality has not been well established. Objective: To assess the association between early initiation of SGLT2i and in-hospital mortality among patients with acute myocardial infarction. Methods: A retrospective, single-center study was conducted on 394 adult patients hospitalized with acute myocardial infarction at Nguyen Trai Hospital, Ho Chi Minh City, between January 2022 and October 2024. The data extraction and analysis were performed from July 31 to October 24, 2024. Patients with incomplete data, secondary acute myocardial infarction, or eGFR

Suggested Citation

  • Hung Thanh Quach & Anh Thi Kim Nguyen & Bao Quoc Dinh & Tuan Minh Nguyen & Hoang Huy Bui & Tuan Ngoc Tran & Tien Dung Ho & An Le Pham & Si Van Nguyen, 2026. "Favorable association between early initiation of sodium-glucose cotransporter-2 inhibitors and in-hospital prognosis in acute myocardial infarction," PLOS ONE, Public Library of Science, vol. 21(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0345315
    DOI: 10.1371/journal.pone.0345315
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