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JC polyomavirus (JCV, HPyV2) seropositivity prevalence in healthy subjects: Systematic review and meta-analysis

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  • Lenka J Kimla
  • David Segal

Abstract

Background: JC polyomavirus (JCV, HPyV2) causes progressive multifocal leukoencephalopathy and has been linked to cancer development. JCV may naturally be highly prevalent in the human population and not just in diseased populations. Objective: The aim of this study was to the estimate the overall seroprevalence of JCV in the healthy human population by age of subjects, region or country of study, and assay methodology. Methods: A systematic review and meta-analysis with meta-regression using STATA 18. Results: Pooled JCV seroprevalence from 25 population-level studies (N = 18,331) was 61% (95% CI, 56% − 66%, z = 33.84, p

Suggested Citation

  • Lenka J Kimla & David Segal, 2026. "JC polyomavirus (JCV, HPyV2) seropositivity prevalence in healthy subjects: Systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 21(1), pages 1-18, January.
    • Handle: RePEc:plo:pone00:0341146
    DOI: 10.1371/journal.pone.0341146
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    References listed on IDEAS

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    1. Lenka J Kimla & Taane G Clark & Sri Banerjee & Susana Campino, 2023. "JC Polyomavirus T-antigen protein expression and the risk of colorectal cancer: Systematic review and meta-analysis of case-control studies," PLOS ONE, Public Library of Science, vol. 18(3), pages 1-15, March.
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