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Apathy in patients with Neuromyelitis Optica Spectrum Disorder

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  • Zihan He
  • Wenjing Li
  • Xinyue Huang
  • Shuai Ma
  • Yuanbin Zhao
  • Shiquan Wang
  • Lili Yang

Abstract

Background: Apathy is a common neuropsychiatric complication of neurological diseases, but it has not been investigated in patients with neuromyelitis optica spectrum disorders (NMOSD) until now. Methods: We enrolled 66 patients diagnosed with NMOSD and assessed apathy using the self-reported version of the Apathy Evaluation Scale (AES-S). All the patients also completed the investigations composed of demographic data, disease characteristics, and composite evaluations of life status, including anxiety/depression, fatigue, sleep, and quality of life. Further statistical analysis proceeded. Results: The mean AES-S score was 36.7 ± 8.3, with 40.9% of patients exhibiting clinically significant apathy (cutoff score: 36). Correlation analysis revealed that higher AES-S scores were significantly correlated with lower education attainment (p = 0.002), more number of attacks (p = 0.008), longer disease duration (p = 0.004), higher disability (p = 0.03), severer anxiety (p

Suggested Citation

  • Zihan He & Wenjing Li & Xinyue Huang & Shuai Ma & Yuanbin Zhao & Shiquan Wang & Lili Yang, 2025. "Apathy in patients with Neuromyelitis Optica Spectrum Disorder," PLOS ONE, Public Library of Science, vol. 20(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0339479
    DOI: 10.1371/journal.pone.0339479
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