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Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia

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  • Qingxia Lin
  • Peifeng Huang
  • Youhong Kang
  • Yanfeng Lu
  • Guili Shi

Abstract

Background: Preeclampsia (PE) is a life-threatening pregnancy disorder lacking reliable early biomarkers. While apoptosis is implicated in PE pathogenesis, the role of regulated necrotic cell death (necroptosis) remains poorly understood. This study aimed to identify necroptosis-related biomarkers, and further provide the potential natural compounds for PE with virtual screening. Methods: Public datasets (GSE66273 for training set; GSE44711 for validation set; GSE173193 for single-cell RNA-seq) were analyzed. Differentially expressed genes (DEGs) were screened using limma (|log2FC| > 1, P

Suggested Citation

  • Qingxia Lin & Peifeng Huang & Youhong Kang & Yanfeng Lu & Guili Shi, 2025. "Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia," PLOS ONE, Public Library of Science, vol. 20(12), pages 1-20, December.
    • Handle: RePEc:plo:pone00:0337546
    DOI: 10.1371/journal.pone.0337546
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