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Health system and household costs of preventive treatment delivery for children exposed to multidrug-resistant tuberculosis in South Africa

Author

Listed:
  • Thomas Wilkinson
  • Suereta Fortuin
  • Anneke C Hesseling
  • H Simon Schaaf
  • Trinh Duong
  • Diana M Gibb
  • Susan E Purchase
  • Lee Fairlie
  • Suzanne Staples
  • Neil Martinson
  • Edina Sinanovic
  • James A Seddon

Abstract

Background: Tuberculosis (TB) preventive treatment (TPT) is a core component of TB control. Levofloxacin was recently recommended by the World Health Organization as TPT in children exposed to multidrug-resistant tuberculosis (MDR-TB). However, the affordability and feasibility of TPT provision for governments, health services, individual households and global donors is uncertain. Methods: This costing analysis used empirical data collected alongside the TB-CHAMP clinical trial which investigated levofloxacin TPT in children exposed to MDR-TB in South Africa. We modelled the societal (health system and household) cost of levofloxacin TPT, other potential future (but not currently recommended) MDR-TB exposure TPT options and compared with drug-susceptible TPT options in children and adolescents under 15 years old. We modelled costs across 12 different medicine and formulation options for 11 paediatric dosing weight-bands using TB-CHAMP and household survey data, with national and international procurement medicine pricing. Results: Total societal costs of providing levofloxacin TPT and its monitoring per child were US$252 (0-

Suggested Citation

  • Thomas Wilkinson & Suereta Fortuin & Anneke C Hesseling & H Simon Schaaf & Trinh Duong & Diana M Gibb & Susan E Purchase & Lee Fairlie & Suzanne Staples & Neil Martinson & Edina Sinanovic & James A Se, 2026. "Health system and household costs of preventive treatment delivery for children exposed to multidrug-resistant tuberculosis in South Africa," PLOS ONE, Public Library of Science, vol. 21(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0336561
    DOI: 10.1371/journal.pone.0336561
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