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Comparative effectiveness of adjuvant treatment for hepatocellular carcinoma with high risk of recurrence: A systematic review and network meta-analysis

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  • Zha Peng
  • Leigu Shen
  • Yaqiong Wang
  • Boyu Chen
  • Zhuangrong Zhu
  • Chengyi He
  • Hai Huang

Abstract

Objective: To identify the most effective postoperative intervention regimen for persons with hepatocellular carcinoma (HCC) at high risk of recurrence. Methods: A network meta-analysis was conducted by collecting eligible studies from Medline, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science databases. Pairwise and network meta-analyses were applied to pooled data on overall survival (OS) and recurrence-free survival (RFS). Results: 35 studies involving 6,372 patients were analyzed. Pairwise meta-analysis showed higher OS (HR = 0.64, 95% CI: 0.56–0.72; P

Suggested Citation

  • Zha Peng & Leigu Shen & Yaqiong Wang & Boyu Chen & Zhuangrong Zhu & Chengyi He & Hai Huang, 2025. "Comparative effectiveness of adjuvant treatment for hepatocellular carcinoma with high risk of recurrence: A systematic review and network meta-analysis," PLOS ONE, Public Library of Science, vol. 20(12), pages 1-17, December.
    • Handle: RePEc:plo:pone00:0335457
    DOI: 10.1371/journal.pone.0335457
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