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Pulmonary vascular and airway changes in previously hospitalised COVID-19 patients: Long-term functional respiratory imaging findings correlate with reduced DLCO

Author

Listed:
  • Ann Mari Svensson
  • Mikael Björnson
  • Magnus Sköld
  • Hans-Ulrich Kauczor
  • Malin Nygren-Bonnier
  • Judith Bruchfeld
  • Michael Runold
  • Anna Kistner
  • Sven Nyrén

Abstract

Background: Persistent respiratory symptoms in COVID-19 patients have raised concerns about structural remodelling in the lung. We assessed structural changes and their correlation with reduced DLCO, eight months after discharge, in previously hospitalised COVID-19 patients. Materials and Methods: An exploratory observational study was conducted on 26 male patients (mean age: 60 years, range: 50–69) previously hospitalised for COVID-19. CT scans, performed eight months post-discharge, were analysed using functional respiratory imaging (FRI) to assess lung structure and function. Analyses were made based on diffusion capacity for carbon monoxide (DLCO). Results: Patients with low DLCO (≤75%; n = 9) exhibited a significantly lower proportion of small blood vessels with a cross-sectional area 75%; n = 17) (median (IQR) 56 (51–59) % vs. 60 (56–64) %, p = 0.008), as well as a reduced absolute volume of small vessels with a cross-sectional area

Suggested Citation

  • Ann Mari Svensson & Mikael Björnson & Magnus Sköld & Hans-Ulrich Kauczor & Malin Nygren-Bonnier & Judith Bruchfeld & Michael Runold & Anna Kistner & Sven Nyrén, 2025. "Pulmonary vascular and airway changes in previously hospitalised COVID-19 patients: Long-term functional respiratory imaging findings correlate with reduced DLCO," PLOS ONE, Public Library of Science, vol. 20(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0335075
    DOI: 10.1371/journal.pone.0335075
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