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Relationship between Gut microbiome and brain volumes among Japanese Men

Author

Listed:
  • Sabrina Ahmed
  • Zhang Hexun
  • Yuichiro Yano
  • Yukiko Okami
  • Nazar Mohd Azahar
  • Keiko Kondo
  • Hisatomi Arima
  • Sayuki Torii
  • Mohammad Moniruzzaman
  • Gantsetseg Ganbaatar
  • Aya Kadota
  • Akira Andoh
  • Akihiko Shiino
  • Hirotsugu Ueshima
  • Katsuyuki Miura
  • for the SESSA Research Group

Abstract

Evidence of preclinical interactions between the gut microbiome and brain health is accumulating. Studies of animal models and specific patient populations have suggested a relationship between gut microbiomes and brain volumes, but this association is understudied in apparently healthy humans. We conducted a population-based cross-sectional study of 623 Japanese men from the Shiga Epidemiological Study on Subclinical Atherosclerosis (SESSA). We performed 16S ribosomal RNA gene sequencing of stool samples collected during the follow-up stage (mean [SD] age, 68.0 [8.0] years; range, 46–83 years). All participants underwent brain magnetic resonance imaging and automated voxel-based morphometry. Principal coordinate analysis, linear discriminant, and multivariable linear regression analyses were performed. In multivariable linear regression analysis, after adjusting for age and total intracranial volume, only gray matter volume showed a positive association with alpha diversity (the Shannon index richness, q-value

Suggested Citation

  • Sabrina Ahmed & Zhang Hexun & Yuichiro Yano & Yukiko Okami & Nazar Mohd Azahar & Keiko Kondo & Hisatomi Arima & Sayuki Torii & Mohammad Moniruzzaman & Gantsetseg Ganbaatar & Aya Kadota & Akira Andoh &, 2025. "Relationship between Gut microbiome and brain volumes among Japanese Men," PLOS ONE, Public Library of Science, vol. 20(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0333612
    DOI: 10.1371/journal.pone.0333612
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