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Integrative GWAS and RNA-Seq analysis for target identification and virtual drug screening in colorectal cancer

Author

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  • Qinghui Liu
  • Yiyang Lei
  • Zixuan Liu
  • Jiale Han

Abstract

Background: Colorectal cancer (CRC) is a leading cause of global cancer-related mortality, necessitating the identification of novel therapeutic targets. Integrating genetic and transcriptomic data may reveal key molecular drivers of CRC progression and treatment opportunities. Methods: We performed a multiomics analysis combining genome-wide association study (GWAS) data (p

Suggested Citation

  • Qinghui Liu & Yiyang Lei & Zixuan Liu & Jiale Han, 2025. "Integrative GWAS and RNA-Seq analysis for target identification and virtual drug screening in colorectal cancer," PLOS ONE, Public Library of Science, vol. 20(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0333179
    DOI: 10.1371/journal.pone.0333179
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