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Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss

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  • Devin J Kennedy
  • Erin Williams
  • Lucienna Wolf
  • Jacquelyn Golden
  • Addison Lana
  • Matthew Wiefels
  • Madeline Pyle
  • Valerie Yunis
  • Michael Hoffer

Abstract

Objectives: Sudden sensorineural hearing loss patient outcomes remain highly variable despite established treatment modalities. This study investigates the effects of treatment modalities, individual-level risk factors, and clinical presentation on sudden sensorineural hearing loss recovery. Methods: Retrospective chart review of n = 231 patients who initiated intratympanic steroids between 01/01/2015-01/01/2025 following sudden sensorineural hearing loss. We collected individual-level risk factors and comprehensive audiometric data. Logistic and linear regression analyses were performed to identify relationships between patient, disease, and treatment-related variables to audiometric recovery (pure-tone average and word recognition score). Segmented linear regression analysis was used to assess the influence of intratympanic steroid treatment delay on patient recovery. Recovery outcomes were determined in accordance with American Academy of Otolaryngology-Head and Neck Surgery criteria. Results: Earlier intratympanic steroid initiation following sudden sensorineural hearing loss symptom onset significantly predicted increased pure-tone average recovery (p

Suggested Citation

  • Devin J Kennedy & Erin Williams & Lucienna Wolf & Jacquelyn Golden & Addison Lana & Matthew Wiefels & Madeline Pyle & Valerie Yunis & Michael Hoffer, 2025. "Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss," PLOS ONE, Public Library of Science, vol. 20(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0332809
    DOI: 10.1371/journal.pone.0332809
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