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Combined application of BNLF2b antibody with VCA-IgA, Rta-IgG, and Zta-IgA in nasopharyngeal carcinoma screening in the Guangxi region

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  • Ruilan Lin
  • Ru Qin
  • Yunlong Zhang
  • Yao Guan
  • Boheng Wu
  • Shangyang Li
  • Shenhong Qu
  • Yulin Yuan

Abstract

Background: This study aims to assess the diagnostic value of the Epstein-Barr virus (EBV) BNLF2b antibody(P85-Ab), alone or in combination with VCA-IgA, Rta-IgG, and Zta-IgA antibodies, in the context of nasopharyngeal carcinoma (NPC). Methods: The study included 100 NPC patients and 100 healthy controls. Chemiluminescent microparticle immunoassay was utilized to measure P85-Ab levels in the serum samples of both NPC patients and healthy controls. Additionally, the ELISA method was employed to detect serum levels of VCA-IgA, Rta-IgG, and Zta-IgA antibodies. The study analyzed the roles of serum P85-Ab in conjunction with VCA-IgA, Rta-IgG, and Zta-IgA antibodies in the diagnosis of NPC. Results: Serum levels of P85-Ab, VCA-IgA, Rta-IgG, and Zta-IgA antibodies in NPC patients were significantly higher than those in the normal control group (P

Suggested Citation

  • Ruilan Lin & Ru Qin & Yunlong Zhang & Yao Guan & Boheng Wu & Shangyang Li & Shenhong Qu & Yulin Yuan, 2025. "Combined application of BNLF2b antibody with VCA-IgA, Rta-IgG, and Zta-IgA in nasopharyngeal carcinoma screening in the Guangxi region," PLOS ONE, Public Library of Science, vol. 20(9), pages 1-9, September.
    • Handle: RePEc:plo:pone00:0332606
    DOI: 10.1371/journal.pone.0332606
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