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The efficacy and safety of electrical acupoint stimulation (EAS) for knee osteoarthritis (KOA): A GRADE-assessed systematic review, meta-analysis and trial sequential analysis

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  • Guangyi Yang
  • Rong Zhang
  • Botan Xu
  • Yi Yang
  • Yuxuan Wang
  • Wenjing Xu
  • Pengwei Li
  • Aotian Yu
  • Simin Ning
  • Qixuan Fu
  • Jianfeng Tu

Abstract

Electrical acupoint stimulation (EAS) is proposed as a potentially beneficial treatment for patients suffering from knee osteoarthritis (KOA). This systematic review and meta-analysis aims to assess the assess the effectiveness and safety of EAS for KOA. To identify eligible RCTs, a systematic search for eligible RCTs is conducted through 6 November 2024 in 12 electronic literature databases, utilizing relevant keywords. The analysis applies a random-effects model to compute RRs and 95% CIs for the dichotomous outcome, alongside the SMD and 95% CIs for continuous outcomes. This meta-analysis includes 63 RCTs with a total of 6475 participants. The pooled analysis reveals that EAS increases the overall response rate by 19.5% (RR: 1.195, 95% CI: 1.130 to 1.264, P

Suggested Citation

  • Guangyi Yang & Rong Zhang & Botan Xu & Yi Yang & Yuxuan Wang & Wenjing Xu & Pengwei Li & Aotian Yu & Simin Ning & Qixuan Fu & Jianfeng Tu, 2025. "The efficacy and safety of electrical acupoint stimulation (EAS) for knee osteoarthritis (KOA): A GRADE-assessed systematic review, meta-analysis and trial sequential analysis," PLOS ONE, Public Library of Science, vol. 20(9), pages 1-27, September.
    • Handle: RePEc:plo:pone00:0331568
    DOI: 10.1371/journal.pone.0331568
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