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Low-dose aspirin is not effective as an adjunct treatment for HIV infection among people living with HIV on dolutegravir-based antiretroviral therapy: A randomised double-blind, parallel-group placebo-controlled trial

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  • Tosi M Mwakyandile
  • Grace A Shayo
  • Philip G Sasi
  • Peter P Kunambi
  • Ferdinand M Mugusi
  • Godfrey Barabona
  • Takamasa Ueno
  • Eligius F Lyamuya

Abstract

Background: Despite virologic suppression with antiretroviral therapy (ART), immune activation (IA) in people living with HIV (PLHIV) remains high and is linked to non-AIDS complications. Alongside its other virologic and immunologic benefits, aspirin promisingly appears to lower the residual IA in PLHIV in small studies. Methods: We conducted a double-blind, parallel-group randomised trial involving ART-naïve PLHIV initiating ART at recruitment. Participants were randomly assigned (1:1) to receive 75 mg aspirin or placebo daily for 24 weeks, alongside standard of care. The primary outcome was proportion of participants attaining HIV viral load 0.05. Conclusions: Low-dose aspirin initiated alongside ART through 24 weeks did not impact virologic or immunologic markers among PLHIV. Trial registration: PACTR202003522049711, NCT05525156

Suggested Citation

  • Tosi M Mwakyandile & Grace A Shayo & Philip G Sasi & Peter P Kunambi & Ferdinand M Mugusi & Godfrey Barabona & Takamasa Ueno & Eligius F Lyamuya, 2025. "Low-dose aspirin is not effective as an adjunct treatment for HIV infection among people living with HIV on dolutegravir-based antiretroviral therapy: A randomised double-blind, parallel-group placebo," PLOS ONE, Public Library of Science, vol. 20(8), pages 1-17, August.
    • Handle: RePEc:plo:pone00:0331087
    DOI: 10.1371/journal.pone.0331087
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