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Corneal biomechanical predictors of intraocular pressure elevation after intravitreal anti-VEGF injection

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Listed:
  • Sayaka Sumi
  • Ryo Asaoka
  • Shuichiro Aoki
  • Kohdai Kitamoto
  • Ryo Terao
  • Mariko Kawata
  • Tatsuya Inoue
  • Ryo Obata
  • Keiko Azuma

Abstract

Purpose: To investigate whether corneal biomechanical parameters measured via Corvis ST can predict acute intraocular pressure (IOP) elevation following intravitreal anti-VEGF injection. Design: Retrospective observational study. Subjects: Forty eyes from patients with neovascular age-related macular degeneration or retinal vein occlusion who underwent anti-VEGF therapy. Methods: IOP was measured using the Corvis ST immediately before and 10 minutes after injection. The following biomechanical parameters were evaluated: DA Ratio MAX (2mm), biomechanically corrected IOP (bIOP), Peak Distance, Deflection Amplitude Max, Integrated Radius, and Stress-Strain Index (SSI). Main outcome measures: Acute post-injection IOP elevation (continuous) and IOP spikes ≥10 mmHg (binary). Results: The mean IOP increased significantly from 14.5 ± 3.17 to 24.7 ± 7.44 mmHg post-injection (p

Suggested Citation

  • Sayaka Sumi & Ryo Asaoka & Shuichiro Aoki & Kohdai Kitamoto & Ryo Terao & Mariko Kawata & Tatsuya Inoue & Ryo Obata & Keiko Azuma, 2025. "Corneal biomechanical predictors of intraocular pressure elevation after intravitreal anti-VEGF injection," PLOS ONE, Public Library of Science, vol. 20(8), pages 1-10, August.
    • Handle: RePEc:plo:pone00:0330574
    DOI: 10.1371/journal.pone.0330574
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