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Impact of clinical pathways on enhancing compliance with evidence-based therapies for Heart failure with reduced ejection fraction–A retrospective cohort study

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  • Naga Sasidhar Kanaparthy
  • Stephen Possick
  • Wei Teng
  • Christopher Maulion
  • Nancy Kim

Abstract

Background: Heart failure (HF) mortality is rising despite robust evidence-based guidelines. Hospitalization presents an opportune time to optimize care. Inpatient care pathways (CP) embedded in the electronic health record (EHR) can enhance adherence to guidelines by providing real-time decision support. Objective: To measure the impact of the heart failure reduced ejection fraction (HFrEF) CP on early diuretic use, goal-directed medical therapy (GDMT), and referral to comprehensive HF management (CHFM) on discharge. Methods: A HFrEF CP embedded into the EHR was built by multidisciplinary providers across a large academic medical center. Providers could place orders and document notes directly from the pathway. We conducted a retrospective cohort study of all the HF hospitalizations two years after pathway implementation and further limited the cohort to those with ejection fraction (EF) ≤ 40%. We compared rates of early diuretic use, GDMT, and referral to CHFM between cohorts defined by pathway use. Results: 1,639 patients contributed 2,062 hospitalizations. The pathway was opened in 362 (17.6%) hospitalizations. There were no significant clinical or sociodemographic differences between groups. Bivariate analyses revealed more GDMT (χ2 (1) = 3.651, p = 0.056); while multivariable analysis showed more early diuretics (OR = 1.58, 95% CI 1.19, 2.09, p = 0.002) and referrals to CHFM (OR = 3.24, 95% CI 2.54, 4.12, p

Suggested Citation

  • Naga Sasidhar Kanaparthy & Stephen Possick & Wei Teng & Christopher Maulion & Nancy Kim, 2025. "Impact of clinical pathways on enhancing compliance with evidence-based therapies for Heart failure with reduced ejection fraction–A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 20(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0330188
    DOI: 10.1371/journal.pone.0330188
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