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Effect of finerenone on urinary protein and inflammatory factor levels in type 2 diabetes mellitus patients with diabetic kidney disease

Author

Listed:
  • Jia Song
  • Yan Kang
  • LiNa Wang
  • YuQing Guo
  • XinJu Jia
  • ShanShan Dong
  • YiMeng Li
  • Dan Wang
  • JingMin Gao
  • AiGe Yang

Abstract

Aims: This study aimed to investigate the efficacy and safety of finerenone in the treatment of diabetic kidney disease (DKD) in the real-world medical setting and explore the underlying mechanism of its kidney-protecting effects from the perspective of the inflammatory response. Materials and Methods: Forty-eight DKD patients were selected and completed a 6-month finerenone treatment. Renal parameters, inflammatory cytokines, other related indicators and adverse effects were collected at every visit. Additionally, subgroup analysis was conducted on the microalbuminuria group (baseline urinary albumin/creatinine ratio (UACR) 30 –

Suggested Citation

  • Jia Song & Yan Kang & LiNa Wang & YuQing Guo & XinJu Jia & ShanShan Dong & YiMeng Li & Dan Wang & JingMin Gao & AiGe Yang, 2025. "Effect of finerenone on urinary protein and inflammatory factor levels in type 2 diabetes mellitus patients with diabetic kidney disease," PLOS ONE, Public Library of Science, vol. 20(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0329965
    DOI: 10.1371/journal.pone.0329965
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