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Risk factors associated with avascular necrosis following unstable slipped capital femoral epiphysis in pediatric patients: A systematic review and meta-analysis

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  • Zihang Xu
  • Lei Zhu
  • Laifa Kong
  • Yuwang Qian
  • Xin Zhang
  • Yuchong Feng
  • Yiming Wu
  • Tao Shi

Abstract

Background: The risk factors for avascular necrosis (AVN) in patients with unstable slipped capital femoral epiphysis (SCFE) were controversial and multifactorial. This meta-analysis summarizes existing evidence to identify risk factors for AVN. Methods: Search strategies followed the recommendations of the Cochrane Collaboration. Electronic searches such as PubMed, Embase, Web of Science, Cochrane were systematically searched for publications concerning risk factors for unstable SCFE from the inception date to October 2024. The RevMan 5.3 software and Stata 17.0 software were used for the meta-analysis. Finally, publication bias and sensitivity analysis were carried out. Results: This study included 16 articles involving 688 hips. We found that the overall incidence of AVN was 23%. Our research indicated that male gender (OR = 2.37; 95% CI = 1.23 to 4.58, P = 0.01), the moderate and severe slip (OR = 0.09; 95% CI = 0.02 to 0.37, P

Suggested Citation

  • Zihang Xu & Lei Zhu & Laifa Kong & Yuwang Qian & Xin Zhang & Yuchong Feng & Yiming Wu & Tao Shi, 2025. "Risk factors associated with avascular necrosis following unstable slipped capital femoral epiphysis in pediatric patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0329275
    DOI: 10.1371/journal.pone.0329275
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