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Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study

Author

Listed:
  • Alice Toschi
  • Renato Pascale
  • Dino Gibertoni
  • Riccardo Pasquali
  • Andrea Grechi
  • Irene Grassi
  • Marta Malosso
  • Ludovica Mangione
  • Cecilia Bonazzetti
  • Beatrice Tazza
  • Matteo Rinaldi
  • Armando Amicucci
  • Caterina Campoli
  • Zeno Pasquini
  • Simone Ambretti
  • Pier Giorgio Cojutti
  • Francesca Bonifazi
  • Pierluigi Viale
  • Maddalena Giannella

Abstract

Importance: Patients with Gram-negative bloodstream infections (GN-BSI) are classified as non-immunocompromised (n-IC) or immunocompromised (IC). However, immunosuppressive condition should not be considered univocally. Objective: To investigate epidemiological characteristics, management and outcome of GN-BSI in IC and non-IC patients. Methods: Retrospective single-center study of hospitalized patients with GN-BSI conducted over a 7-year period. Patients with GN-BSI were divided in: solid organ transplant (SOT) recipients, patients with hematologic malignancy (HM), patients with metastatic solid cancer (mSC), and non-major IC patients (nm-IC). Results: 3544 patients analysed: 76.7% nm-IC, 6.5% SOT, 8.0% HM and 8.8% mSC. SOT and HM patients were younger (SOT: 56.6 ± 13.1 years; HM: 56.4 ± 14.5; nm-IC: 72.4 ± 16.1; mSC: 68.6 ± 13.1, p

Suggested Citation

  • Alice Toschi & Renato Pascale & Dino Gibertoni & Riccardo Pasquali & Andrea Grechi & Irene Grassi & Marta Malosso & Ludovica Mangione & Cecilia Bonazzetti & Beatrice Tazza & Matteo Rinaldi & Armando A, 2025. "Epidemiological characteristics and management of Gram-negative bacteraemia in different immunocompromised hosts: Observational single-center study," PLOS ONE, Public Library of Science, vol. 20(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0327535
    DOI: 10.1371/journal.pone.0327535
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