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Impact of monitor unit optimization in volumetric modulated arc therapy planning for nasopharyngeal carcinoma

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  • Huaqu Zeng
  • Zhen Li
  • Zongyou Chen
  • Shukui Tang
  • Qifu Lin
  • Minzhi Zhong
  • Zunbei Wen

Abstract

Purpose: To evaluate the impact of monitor units (MUs) optimization on volumetric modulated arc therapy (VMAT) plan for nasopharyngeal carcinoma (NPC). Methods: Twenty-one NPC patients were retrospectively analyzed. Dual-arc VMAT plan were designed using photon optimization algorithms without the monitor unit objective (MUO) tool, denoted as the base plan. Each base plan was re-optimized with the MUO tool with the Maximum MU parameter set to 30% of the base plans’ total MUs and Strength parameters set to 50, 80, and 100, generating plans S50, S80, and S100. Target and organ-at-risk (OAR) dose distributions, MUs, beam delivery time, and gamma passing rates were compared between re-optimized and base plans. Statistical analysis was performed using SPSS 17.0 (paired t-tests; significance: P 4% (relative to the base plan) in four patients. Plan S80 reduced target PGTV and PGTVnd Dmax and target PCTV2 D98% for >3% but

Suggested Citation

  • Huaqu Zeng & Zhen Li & Zongyou Chen & Shukui Tang & Qifu Lin & Minzhi Zhong & Zunbei Wen, 2025. "Impact of monitor unit optimization in volumetric modulated arc therapy planning for nasopharyngeal carcinoma," PLOS ONE, Public Library of Science, vol. 20(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0327153
    DOI: 10.1371/journal.pone.0327153
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