Author
Listed:
- María Victoria Waks-Serra
- Demián Augusto Vera
- Nicolás Abel Carbone
- Héctor Alfredo García
- Pamela Alejandra Pardini
- Juan Antonio Pomarico
- Daniela Inés Iriarte
Abstract
Significance:: Continuous-wave near-infrared spectroscopy (CW-NIRS) is a valuable, inexpensive and non-invasive tool for complementary diagnose breast cancer. The use of phantoms has proven to be a very powerful way to evaluate different experimental approaches as well as to test possible diagnostics equipment. The phantoms developed in this work can properly emulate either benign or malignant tumors and, in contrast to those constructed with actual biological chromophores, require no special storage, being thus stable in time. Aim:: In this work we study the feasibility of employing two artificial absorbents as a replacement for oxygenated and deoxygenated hemoglobin concentrations in breast tumors, allowing discrimination benign from malignant tumors in CW transmittance NIRS experiments. Approach:: Tumor phantoms were made of epoxy resin containing two kinds of absorbents to emulate the absorption curves of the hemoglobins in concentrations that reproduce those of benign and malignant tumors (fibroadenoma and adenocarcinoma respectively). CW transmittance NIRS experiments were carried out to evaluate the approach which was also compared with Monte Carlo (MC) simulations. Results:: Results show that the constructed tumor phantoms are feasible to reproduce the desired targets. Additionally, the retrieved concentrations agree with the proposed ones. Thus, it is possible to construct a phantom containing inclusions emulating a fibroadenoma and/or an adenocarcinoma suitable for testing mammography algorithms or equipment. Conclusions:: We have successfully designed, constructed, and validated tumor phantoms emulating both benign and malignant breast tumors. The transmittance experiments carried out agree very well with MC simulations. In addition, it was possible to obtain a map of absorbent concentrations recovered from the diffuse imaging experiments.
Suggested Citation
María Victoria Waks-Serra & Demián Augusto Vera & Nicolás Abel Carbone & Héctor Alfredo García & Pamela Alejandra Pardini & Juan Antonio Pomarico & Daniela Inés Iriarte, 2025.
"Solid breast tumors phantom emulating oxy and deoxyhemoglobin concentrations for near infrared imaging,"
PLOS ONE, Public Library of Science, vol. 20(6), pages 1-22, June.
Handle:
RePEc:plo:pone00:0325768
DOI: 10.1371/journal.pone.0325768
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0325768. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.