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Prognostic impact of HER2-low expression in triple-negative breast cancer of high-grade special histological type and no special type

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Listed:
  • Claudia Grosse
  • Petar Noack
  • Alexandra Grosse
  • Heike Kathleen Schwarz
  • Peter Schrenk
  • Heike Frauchiger-Heuer
  • Rupert Langer
  • Zsuzsanna Varga

Abstract

Interest in HER2-low breast cancer has grown in recent years due to advancements in novel anti-HER2 antibody-drug conjugates. This study examined the impact of HER2-low expression on survival outcomes in triple-negative breast cancer (TNBC) of high-grade special histological type (ST) and no special type (NST) and investigated the prognostic significance of TNBC subtype (high-grade ST vs. NST) within HER2 0 and HER2-low expression subgroups. Clinicopathological and survival data of 504 patients with stage I-III TNBC, with or without neoadjuvant chemotherapy (NAC), were analyzed, including 400 patients with TNBC NST and 104 patients with high-grade TNBC ST. HER2-low status was not identified as an independent prognostic factor for survival in the overall cohort, nor within the high-grade TNBC ST and TNBC NST subgroups. Among patients who did not receive NAC, TNBC subtype (high-grade ST vs. NST) was independently associated with DDFS and DFS in the HER2 0 subgroup, but not in the HER2-low subgroup. Patients with HER2 0 high-grade TNBC ST exhibited significantly worse OS (p = 0.008), DDFS (p

Suggested Citation

  • Claudia Grosse & Petar Noack & Alexandra Grosse & Heike Kathleen Schwarz & Peter Schrenk & Heike Frauchiger-Heuer & Rupert Langer & Zsuzsanna Varga, 2025. "Prognostic impact of HER2-low expression in triple-negative breast cancer of high-grade special histological type and no special type," PLOS ONE, Public Library of Science, vol. 20(6), pages 1-19, June.
    • Handle: RePEc:plo:pone00:0325715
    DOI: 10.1371/journal.pone.0325715
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