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Association of triglyceride glucose-body mass index (TyG-BMI) with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis

Author

Listed:
  • Yasaman Ghodsi Boushehri
  • Zahra Meymanatabadi
  • Ali Ezzatollahi Tanha
  • Pouria Azami
  • Maryam Alaei
  • Amir Ali Alamdari
  • Hooman Momtazi
  • Nasrin Deilami Moezzi
  • Amirhossein Habibzadeh
  • Shaghayegh Khanmohammadi

Abstract

Background: TyG-BMI has been proposed as a marker of insulin resistance in metabolic-associated fatty liver disease, but its clinical utility remains uncertain. This study aims to evaluate the association between TyG-BMI and metabolic dysfunction-associated steatotic liver disease (MASLD) through a systematic review and meta-analysis, focusing on the diagnostic performance across different subgroups. Methods: A comprehensive literature search was conducted in PubMed, Scopus, Embase, and Web of Science up to January 20, 2025. Studies evaluating the relationship between TyG-BMI and MASLD in adults were included. A random-effects model was employed to pool effect sizes, and subgroup analyses were conducted based on sex, disease definition, and population type. Results: Thirty-five studies with 339,087 participants were included. The pooled mean difference for TyG-BMI between MASLD and non-MASLD groups was 42.72 (95% CI: 35.93–49.51; p

Suggested Citation

  • Yasaman Ghodsi Boushehri & Zahra Meymanatabadi & Ali Ezzatollahi Tanha & Pouria Azami & Maryam Alaei & Amir Ali Alamdari & Hooman Momtazi & Nasrin Deilami Moezzi & Amirhossein Habibzadeh & Shaghayegh , 2025. "Association of triglyceride glucose-body mass index (TyG-BMI) with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(8), pages 1-29, August.
    • Handle: RePEc:plo:pone00:0324483
    DOI: 10.1371/journal.pone.0324483
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