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Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis

Author

Listed:
  • Solima Sabeel
  • Bongani Motaung
  • Kim A Nguyen
  • Mumin Ozturk
  • Sandra L Mukasa
  • Karen Wolmarans
  • Dirk J Blom
  • Karen Sliwa
  • Emmanuel Nepolo
  • Gunar Günther
  • Robert J Wilkinson
  • Claudia Schacht
  • Andre Pascal Kengne
  • Friedrich Thienemann
  • Reto Guler

Abstract

While numerous studies have extensively documented the pleiotropic effects of statins, including their capacity to reduce inflammation, there is a lack of research estimating the anti-inflammatory effectiveness of statins among individuals with chronic diseases. This meta-analysis evaluates the effect of statin therapy on inflammatory markers and the lipid profile in patients with chronic diseases by analysing evidence from randomized controlled trials (RCTs). We conducted a systematic review and searched articles published between 1st January 1999 and 31st December 2023 in databases including PubMed, Web of Science, Scopus, and Cochrane. The meta-analysis was performed using random effects models and inverse variance. Effect measures were mean differences (MD) and 95% confidence intervals (CI). Collectively, statins significantly reduced IL-6 (MD = -0.24 ng/dL [95% CI, -0.36 to -0.13], I2 = 98.3%, p

Suggested Citation

  • Solima Sabeel & Bongani Motaung & Kim A Nguyen & Mumin Ozturk & Sandra L Mukasa & Karen Wolmarans & Dirk J Blom & Karen Sliwa & Emmanuel Nepolo & Gunar Günther & Robert J Wilkinson & Claudia Schacht &, 2025. "Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(5), pages 1-20, May.
    • Handle: RePEc:plo:pone00:0323749
    DOI: 10.1371/journal.pone.0323749
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