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Development of a novel risk score for diagnosing urinary tract infections: Integrating Sysmex UF-5000i urine fluorescence flow cytometry with urinalysis

Author

Listed:
  • Vo Anh Vinh Trang
  • Thien Tan Tri Tai Truyen
  • Minh Thuan Nguyen
  • Huu Phong Mai
  • Tri Cuong Phan
  • Son Hoang Phan
  • Han My Le Nguyen
  • Huong-Dung Thi Nguyen
  • Nguyen Hai Dang Le
  • Man Nhi Tu
  • Vo Thanh Vi Huynh
  • Hoang Tram Anh Nguyen
  • Dac Bao Han Ho
  • Ngoc Thuy Uyen Tran
  • Nguyen Ha Uyen Tran
  • Bich-Nhat Thi Le
  • Duc Tuan Doan
  • Huu Doan Pham
  • Truong Bao Phan
  • Phu Phat Pham
  • Tuan Vinh Nguyen
  • Phuc Cam Hoang Nguyen

Abstract

Background: Urinary tract infections (UTIs) are common globally, and are developing increased antibiotic resistance. Despite being the diagnostic “gold standard,” urine culture is limited by slow results and a high rate of false negative findings, leading to treatment delays, higher costs, and overuse of empirical antibiotics. Our study aims to develop a rapid and reliable model to predict clinical outcomes. Methods: From January 1st to October 31st, 2023, we enrolled patients with symptoms suggesting UTI from the Outpatient Department of our hospital. Inclusion criteria were patients aged ≥18, initially diagnosed with UTI, available urinalysis, flow cytometry, and urinary culture. Exclusion criteria included failed sample collection and cultures, and pregnant women. A case-control study was conducted, with UTI cases defined as ≥ 10^5 CFU/ µ L and controls as

Suggested Citation

  • Vo Anh Vinh Trang & Thien Tan Tri Tai Truyen & Minh Thuan Nguyen & Huu Phong Mai & Tri Cuong Phan & Son Hoang Phan & Han My Le Nguyen & Huong-Dung Thi Nguyen & Nguyen Hai Dang Le & Man Nhi Tu & Vo Tha, 2025. "Development of a novel risk score for diagnosing urinary tract infections: Integrating Sysmex UF-5000i urine fluorescence flow cytometry with urinalysis," PLOS ONE, Public Library of Science, vol. 20(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0323664
    DOI: 10.1371/journal.pone.0323664
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