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Predictability of clinical outcomes after external beam radiotherapy for hepatocellular carcinoma according to tumor marker dynamics

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  • Sunmin Park
  • Chai Hong Rim
  • Young Kul Jung
  • Hyung Joon Yim
  • Hwan Hoon Chung
  • Won Sup Yoon

Abstract

Signal changes after high dose irradiation on MRI make it difficult to assess the therapeutic response of hepatocellular carcinoma (HCC). To overcome the limitation of imaging work-up, our study predicted clinical outcomes through tumor marker dynamics in HCC after external beam radiotherapy (EBRT). As a single-center retrospective study, those who underwent conventional fractionated EBRT for viable HCC from 2010 to 2021 were analyzed. Patients with elevated tumor markers of AFP ≥ 10 ng/ml or PIVKA-II ≥ 30 mAU/ml before EBRT were enrolled. Remission of AFP, PIVKA-II, and MoRAL score (=11*√PIVKA-II + 2*√AFP) from pre-EBRT to post-EBRT at 1 month and 3 months was examined. For 1-year and 2-years OS, variables of tumor markers were examined using the receiver operation characteristics (ROC). Multivariate analyses of Cox-regression for OS were conducted. Among 111 patients, 34 patients were estimated to survive more than 2-years. In multivariate analyses for OS, tumor number (P = 0.004), portal vein tumor thrombus (P = 0.004), and Barcelona liver cancer staging (P

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  • Sunmin Park & Chai Hong Rim & Young Kul Jung & Hyung Joon Yim & Hwan Hoon Chung & Won Sup Yoon, 2025. "Predictability of clinical outcomes after external beam radiotherapy for hepatocellular carcinoma according to tumor marker dynamics," PLOS ONE, Public Library of Science, vol. 20(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0323450
    DOI: 10.1371/journal.pone.0323450
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