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Effect of lipid-lowering therapies on flow-mediated dilation in patients: A systematic review and meta-analysis of clinical randomized controlled trials

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  • Xinyue Wang
  • Lijun Zhou
  • Qiutao Wang
  • Min Wu

Abstract

Numerous lipid-lowering medications are commonly used in clinical settings; however, their impact on vascular endothelial function remains unclear. This study employed techniques like flow-mediated dilation (FMD) to demonstrate the relative effects of lipid-lowering medications on vascular function. PubMed, Embase, and World of Science were searched from January 1, 2011 to October 1, 2024, and the language was limited to English. Randomized controlled trials (RCTs) have assessed the impact of lipid-lowering medications versus placebos on FMD in individuals. The outcomes included FMD, pulse wave velocity (PWV), low-density lipoprotein cholesterol (LDL-C), peak O2 consumption (VO2), and intimal media thickness (IMT). We computed standardized mean differences and 95% confidence intervals (CIs). P

Suggested Citation

  • Xinyue Wang & Lijun Zhou & Qiutao Wang & Min Wu, 2025. "Effect of lipid-lowering therapies on flow-mediated dilation in patients: A systematic review and meta-analysis of clinical randomized controlled trials," PLOS ONE, Public Library of Science, vol. 20(6), pages 1-18, June.
    • Handle: RePEc:plo:pone00:0323210
    DOI: 10.1371/journal.pone.0323210
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