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Exploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independent samples

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  • Ying Zhao
  • Cong Yu
  • Hengchang Sun
  • Fangmei Xie
  • Jian Shen
  • Xiaoming Li
  • Xiaoyu Song
  • Wenfeng Luo
  • Jinhua He
  • Zeping Han

Abstract

Idiopathic sudden sensorineural hearing loss (ISSNHL) is defined by the rapid onset of hearing impairment without an identifiable etiology. The decreased serum concentrations of 25-hydroxyvitamin D(25(OH)D) was shown to be associated with decreased hearing ability. However, current cross-sectional studies have only demonstrated an association, failing to establish a causal link. Therefore, a comprehensive investigation is necessary to clarify the causal relationship between them. Analysis was done by using largescale genome-wide association analysis(GWAS) summary datasets to give information about the incidence of ISSNHL and genetically predicted serum 25(OH)D levels by a two-sample Mendelian randomization (MR) analysis. Instrumental variables (IVs) were identified as genome-wide significant single-nucleotide polymorphisms (SNPs) with a significance threshold of P

Suggested Citation

  • Ying Zhao & Cong Yu & Hengchang Sun & Fangmei Xie & Jian Shen & Xiaoming Li & Xiaoyu Song & Wenfeng Luo & Jinhua He & Zeping Han, 2025. "Exploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independ," PLOS ONE, Public Library of Science, vol. 20(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0322898
    DOI: 10.1371/journal.pone.0322898
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