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Measles vaccines and non-specific effects on mortality or morbidity: A systematic review and meta-analysis

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  • Louise A Fournais
  • Anne C Zimakoff
  • Andreas Jensen
  • Jeppe H Svanholm
  • Ingvild Fosse
  • Lone G Stensballe

Abstract

Background: This review evaluates the hypothesis of beneficial non-specific effects of the standard-titre measles vaccine. Methods: We conducted a systematic review and meta-analysis of randomised controlled trials. Trials included standard or high-titre live attenuated measles containing vaccines compared to other vaccines or placebo. The primary outcomes were mortality and morbidity. Secondary outcomes were infections, antibiotic use, atopy, allergies, asthma, and atopic dermatitis. Findings: 23 articles were included in this systematic review. Interpretation: Based on evidence from randomised controlled trials, this systematic literature review and meta-analysis did not support the hypothesis of non-specific effects of standard-titre measles containing vaccines. Trial Sequential Analysis indicated that the meta-analysis included sufficient data to reach this conclusion. Trial registration: PROSPERO CRD42022344473

Suggested Citation

  • Louise A Fournais & Anne C Zimakoff & Andreas Jensen & Jeppe H Svanholm & Ingvild Fosse & Lone G Stensballe, 2025. "Measles vaccines and non-specific effects on mortality or morbidity: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0321982
    DOI: 10.1371/journal.pone.0321982
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