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Association of albumin-bilirubin grade with survival outcomes in patients with cholangiocarcinoma

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Listed:
  • Jing Ye
  • Rongqiang Liu
  • Jianguo Wang
  • Wangbin Ma
  • Chen Chen
  • Jia Yu
  • Weixing Wang

Abstract

Background: Numerous studies have reported the association between preoperative albumin-bilirubin (ALBI) grade and survival outcomes in patients with cholangiocarcinoma (CCA). However, the results are inconsistent. Therefore, we conducted a meta-analysis to comprehensively evaluate the relationship between ALBI grade and prognosis of CCA patients. Methods: We retrieved the databases (Pubmed,Embase and Web of science) to search articles about the association of ALBI grade with prognostic value in CCA patients. Hazard ratios (HR) and 95% confidence intervals (CI) were used to summarize survival outcomes. STATA 12.0 was used to implement the data analyses. Results: 11 studies from 10 articles comprising 2841 patients were included in the meta-analysis. The pooled results showed that high ALBI grade was significantly associated with poor overall survival (OS) (HR: 1.75, 95% CI: 1.32–2.31) and relapse-free survival(RFS)(HR:1.95;95%CI:1.37–2.13). Subgroup analysis further showed that high ALBI grade had better predictive value for Asian population(HR:1.92;95%CI:1.46–2.51). Sensitivity analysis indicated that the results of the meta-analysis were stable. Conclusions: High ALBI grade predicted adverse survival outcomes in CCA patients. ALBI grade may be an efficient and convenient prognostic indicator in CCA patients for Asian population.

Suggested Citation

  • Jing Ye & Rongqiang Liu & Jianguo Wang & Wangbin Ma & Chen Chen & Jia Yu & Weixing Wang, 2025. "Association of albumin-bilirubin grade with survival outcomes in patients with cholangiocarcinoma," PLOS ONE, Public Library of Science, vol. 20(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0321758
    DOI: 10.1371/journal.pone.0321758
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