Hepatitis B virus: Prevalence, vaccination coverage and immune responses to immunization among healthcare workers at Muhimbili National Hospital

Background: Healthcare workers (HCWs) are at an increased risk of contracting and transmitting the hepatitis B virus (HBV). Vaccination coverage against HBV a cost- effective prevention, remains low among HCWs in some settings. Objective: To determine the prevalence of HBV infection, vaccination coverage, and immune responses to HBV vaccine among HCWs at Muhimbili National Hospital (MNH) in Dar es Salaam. Methodology: This cross-sectional study used a proportional probability systematic sampling to recruit HCWs from MNH in Dar es Salaam. A structured questionnaire was used to collect social demographic characteristics, infection prevention and control practices, HBV vaccination status and reasons for not vaccinating. Five mLs of a peripheral venous sample was obtained from each participant, the sample was used to test for HBV surface antigen, HBV surface antibody and HBV core antibody for assessing for infection, and vaccine immunity respectively. A Robust Poisson Regression analysis was used to assess factors associated with not vaccinating. Results: The prevalence of HBV infection was 5 (1.2%) among the 415 recruited HCWs. Only 192 (46.3%) HCWs were vaccinated and 169 (96%) had protective immunity against HBV infection among 176 participants who had received at least two vaccine doses. HCWs who were laboratory scientist aPR = 2.01, 95% CI (1.35–3.00) and had