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Evaluation of the utility of cardiac biomarkers for risk stratification in patients with lower extremity artery disease: A retrospective study

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  • Leyla Schweiger
  • Reinhard B Raggam
  • Gabor Toth-Gayor
  • Philipp Jud
  • Alexander Avian
  • Viktoria Nemecz
  • Katharina Gütl
  • Marianne Brodmann
  • Thomas Gary

Abstract

Critical limb threatening ischemia (CLTI) is associated with a one-year mortality rate of up to 25% making prompt diagnosis essentially. This study aims to investigate if cardiac biomarkers may serve as an effective tool for risk stratification in patients with lower extremity artery disease (LEAD). For this cross-sectional retrospective analysis, 21712 patients with LEAD were screened for eligibility from 2004 to 2020. Out of these patients, 367 were included and subdivided into those with CLTI and those without CLTI. Cardiac biomarkers, including N-terminal prohormone of brain natriuretic peptide (NT-proBNP), troponin, NT-proBNP/troponin ratio, creatin kinase myocardial band (CK-MB) and myoglobin, were retrospectively analyzed. Fifty-nine patients had CLTI (16.1%) with higher rates of NT-proBNP, NT-proBNP/troponin ratio, CK-MB and myoglobin (all p

Suggested Citation

  • Leyla Schweiger & Reinhard B Raggam & Gabor Toth-Gayor & Philipp Jud & Alexander Avian & Viktoria Nemecz & Katharina Gütl & Marianne Brodmann & Thomas Gary, 2025. "Evaluation of the utility of cardiac biomarkers for risk stratification in patients with lower extremity artery disease: A retrospective study," PLOS ONE, Public Library of Science, vol. 20(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0321491
    DOI: 10.1371/journal.pone.0321491
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