IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0321353.html
   My bibliography  Save this article

Does financial compensation matter for research participation in prevention trials in Tanzania? Perspectives of healthy volunteers

Author

Listed:
  • Raymond Athanas
  • Heavenlight A Paulo
  • Gasto Frumence
  • Masunga K Iseselo
  • Connie M Ulrich

Abstract

Background: Financial compensation is an important aspect of respect for people enrolled in clinical research, yet continues to raise ethical questions. Respondents’ characteristics, shaped by contextual and geographic factors, may influence perceptions of the ethical implications of financial compensation. This study explored the relationship between respondents’ characteristics and their ethical perspective on the role of financial compensation in prevention trials in Tanzania. Materials and methods: A cross-sectional survey of 537 participants from two prevention studies within Tanzania was conducted. Participants were eligible if they participated in either the HIV Pre-Exposure Prophylaxis Vaccine Trial (PrEPVacc) trial or a non-inferiority trial of low-dose compared to standard high-dose calcium supplementation in pregnancy in Tanzania. A questionnaire was used to collect participants’ sociodemographic characteristics and motivating reasons for research participation. Data analysis was performed using descriptive statistics for all variables. The chi-square test was used to assess associations between categorical demographic characteristics and binary outcomes scores. Modified Poisson regression models were employed to examine predictors of positive or negative perspectives for each outcome. The P value of

Suggested Citation

  • Raymond Athanas & Heavenlight A Paulo & Gasto Frumence & Masunga K Iseselo & Connie M Ulrich, 2025. "Does financial compensation matter for research participation in prevention trials in Tanzania? Perspectives of healthy volunteers," PLOS ONE, Public Library of Science, vol. 20(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0321353
    DOI: 10.1371/journal.pone.0321353
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0321353
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0321353&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0321353?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0321353. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.