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Emerging trends and disparities in cardiovascular, kidney, and diabetes-related mortality: A retrospective analysis of the wide-ranging online data for epidemiologic research database

Author

Listed:
  • Aman Goyal
  • Humza Saeed
  • Samia Aziz Sulaiman
  • Wania Sultan
  • Momina Riaz Siddiqui
  • Mah I Kan Changez
  • Arman Qamar
  • Sarju Ganatra
  • Sourbha S Dani

Abstract

Introduction: Cardiovascular-kidney-metabolic (CKM) syndrome, driven by metabolic risk factors like obesity, type 2 diabetes (DM-2), chronic kidney disease (CKD), and cardiovascular disease (CVD), leads to poorer health outcomes. Despite its rising prevalence and promising new therapies, trends and demographic disparities in CKM-related mortality among adults in the United States remain underexplored. Methodology: The study examined CDC WONDER death certificates for individuals aged 25+ who died from 1999 to 2022, with CVD as the main cause, while CKD and DM-2 as contributing factors. Age-adjusted mortality rates (AAMRs) and annual percent change (APC) were calculated by year, sex, age, race/ethnicity, region, and urbanization status. Results: From 1999 to 2022, 25,980 CKM-related deaths were recorded, with the AAMR decreasing from 5.3 to 0.4 per 1,000,000 population. AAMR rose significantly from 1999 to 2012 (APC: 7.03; p

Suggested Citation

  • Aman Goyal & Humza Saeed & Samia Aziz Sulaiman & Wania Sultan & Momina Riaz Siddiqui & Mah I Kan Changez & Arman Qamar & Sarju Ganatra & Sourbha S Dani, 2025. "Emerging trends and disparities in cardiovascular, kidney, and diabetes-related mortality: A retrospective analysis of the wide-ranging online data for epidemiologic research database," PLOS ONE, Public Library of Science, vol. 20(5), pages 1-16, May.
    • Handle: RePEc:plo:pone00:0320670
    DOI: 10.1371/journal.pone.0320670
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