IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0320523.html
   My bibliography  Save this article

The impact of brominated flame retardants exposure on serum total bilirubin: A cross-sectional analysis

Author

Listed:
  • Shanshan Huang
  • Tong Lin
  • Jialu Chen
  • Fen Zhou
  • Junjie Yang
  • Haiyan Mao
  • Zhouxin Yang

Abstract

Background: Brominated flame retardants (BFRs) are harmful, bioaccumulative, and persistent environmental pollutants, posing significant health risks. Elevated bilirubin levels can cause neurotoxicity and damage to the heart, liver, kidneys, and other organs. This study utilizes National Health and Nutrition Examination Survey (NHANES) data to investigate the association between exposure to BFRs and total bilirubin (TB) levels in adult participants. Methods: Based on data from the NHANES 2007-2016, TB levels were divided into tertiles. Spearman’s rank correlation was used to analyze the relationship between individual BFRs and TB levels. Weighted linear regression analysis, restricted cubic splines (RCS), and stratified analysis were conducted to assess the correlation between individual BFRs and TB levels. Weighted quantile sum (WQS) regression and quantile-based g-computation (QGC) analysis were used to comprehensively evaluate the impact of BFRs exposure on serum TB levels. Results: The study included 5831 participants. The results showed that PBB153, PBDE17, PBDE47, PBDE85, PBDE99, PBDE100, PBDE209, and PBDE183 were significantly correlated with TB levels (p

Suggested Citation

  • Shanshan Huang & Tong Lin & Jialu Chen & Fen Zhou & Junjie Yang & Haiyan Mao & Zhouxin Yang, 2025. "The impact of brominated flame retardants exposure on serum total bilirubin: A cross-sectional analysis," PLOS ONE, Public Library of Science, vol. 20(3), pages 1-14, March.
    • Handle: RePEc:plo:pone00:0320523
    DOI: 10.1371/journal.pone.0320523
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0320523
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0320523&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0320523?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0320523. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.