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Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan

Author

Listed:
  • Naomi Maeda
  • Masayuki Koyama
  • Shintaro Takatsuka
  • Keisuke Oyatani
  • Nobuaki Himuro
  • Tasuku Mariya
  • Yoshika Kuno
  • Shiro Hinotsu
  • Tsuyoshi Saito
  • Hirofumi Ohnishi

Abstract

Background: Hypertensive disorders of pregnancy (HDP) significantly increase the risk of developing hypertension and cardiovascular disease (CVD) later in life and are a major cause of maternal mortality. However, little is known about the nationwide, long-term, all-inclusive status of HDP. Objective: To estimate the incidence of HDP from 2011 to 2019 in Hokkaido, Japan, with a focus on age groups. Methods: Using National Database (NDB) insurance medical data, a retrospective analysis was conducted. Due to the absence of direct pregnancy data, birth numbers were used as a surrogate for the number of pregnant women to calculate the incidence of HDP. Results: The average incidence rate of HDP over 9 years was 6.37%. The incidence rate was lowest among women aged 25–29 years, at 5.58% (95% confidence interval [CI]: 5.43–5.73), and increased with age, peaking at 10.58% (95% CI: 10.10–11.09) among women over 40 years. Notably, the incidence rate for women under 20 years of age was 6.70% (95% CI: 5.97–7.51), which was higher than that for women in their 20s. A mean annual increase of 0.25% in age-adjusted incidence was observed during this period, which was statistically significant (R² = 0.87, p

Suggested Citation

  • Naomi Maeda & Masayuki Koyama & Shintaro Takatsuka & Keisuke Oyatani & Nobuaki Himuro & Tasuku Mariya & Yoshika Kuno & Shiro Hinotsu & Tsuyoshi Saito & Hirofumi Ohnishi, 2025. "Maternal age and the rising incidence of hypertensive disorders of pregnancy: A comprehensive analysis of national claims data from Japan," PLOS ONE, Public Library of Science, vol. 20(2), pages 1-17, February.
    • Handle: RePEc:plo:pone00:0319177
    DOI: 10.1371/journal.pone.0319177
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