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Global prevalence of elevated estimated pulmonary artery systolic pressure in clinically stable children and adults with sickle cell disease: A systematic review and meta-analysis

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  • Mobin Ghazaiean
  • Hadi Darvishi-Khezri
  • Behnam Najafi
  • Hossein Karami
  • Mehrnoush Kosaryan

Abstract

Background: The current study sought to determine the prevalence of elevated estimated pulmonary artery systolic pressure (ePASP) in clinically stable children and adults with sickle cell disease)SCD(worldwide. Methods: The studies included were identified through a search of databases such as PubMed, Scopus, Science Direct, Web of Science, and Embase, as well as Google Scholar engine, adhering to specific inclusion and exclusion criteria. Heterogeneity among the primary study results was assessed using the I-squared index, while publication bias was evaluated through funnel plots, Egger’s test, and trim and fill analysis. All statistical analyses were conducted using R software, version 4.3.0. Results: 79 primary studies were included, comprising 6,256 children (

Suggested Citation

  • Mobin Ghazaiean & Hadi Darvishi-Khezri & Behnam Najafi & Hossein Karami & Mehrnoush Kosaryan, 2025. "Global prevalence of elevated estimated pulmonary artery systolic pressure in clinically stable children and adults with sickle cell disease: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(2), pages 1-31, February.
    • Handle: RePEc:plo:pone00:0318751
    DOI: 10.1371/journal.pone.0318751
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