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Explore the possible influence of Sjogren’s syndrome on thyroid cancer: A literature data mining and meta-analysis

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Listed:
  • Fanyong Kong
  • Boxuan Han
  • Zhen Wu
  • Jiaming Chen
  • Xixi Shen
  • Qian Shi
  • Lizhen Hou
  • Jugao Fang
  • Meng Lian

Abstract

Objectives: To explore the potential influence of Sjogren’s syndrome (SS) on thyroid cancer (TC). Methods: First, a literature data mining (LDM) approach was used to reconstruct functional pathways connecting SS and TC. A meta-analysis was then performed to examine the expression changes of genes mediated by SS using 16 TC case/control expression datasets, with results validated through the TCGA/GTEx dataset. Finally, gene set enrichment analysis (GSEA) and survival analysis using GEPIA2 were conducted on the significant genes. Results: Our findings indicate that SS may increase the risk of TC by activating 14 TC promoters (PDCD1, NTRK1, LGALS3, CD274, FOXP3, BCL2, CYP1A1, HMGB1, TGFB1, CCL2, PLA2G7, TFF3, LCN2, and CLDN1) and suppressing three TC inhibitors (MIR145, MIR30C1, and EP300). Four molecules (PLA2G7, TFF3, LCN2, and CLDN1) exhibited significant expression changes in TC patients (LFC > 1 or

Suggested Citation

  • Fanyong Kong & Boxuan Han & Zhen Wu & Jiaming Chen & Xixi Shen & Qian Shi & Lizhen Hou & Jugao Fang & Meng Lian, 2025. "Explore the possible influence of Sjogren’s syndrome on thyroid cancer: A literature data mining and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(2), pages 1-18, February.
    • Handle: RePEc:plo:pone00:0318747
    DOI: 10.1371/journal.pone.0318747
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