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Increased sagittal abdominal diameter is associated with a higher risk of kidney stones

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  • Wei Song
  • Shugen Li
  • Guangchun Wang
  • Shang Gao

Abstract

Background: This study investigates the relationship between sagittal abdominal diameter (SAD), a measure of abdominal obesity, and kidney stone disease (KSD) in the U.S. population. Additionally, it explores potential underlying mechanisms and evaluates the clinical utility of a predictive model. Methods: Data were collected from 11,671 participants, including 1,136 cases of KSD. Univariate and multivariate logistic regression analyses, dose-response curves, and mediation effect assessments were employed to examine the association between SAD and KSD. A predictive model was developed and validated using calibration curves, receiver operating characteristic (ROC) curves, and clinical decision curves. Additionally, hematological indicators were analyzed to identify potential mediating factors. Results: SAD showed a strong and positive association with KSD, even after adjusting for confounders such as gender, age, and education. The predictive model demonstrated moderate accuracy (AUC = 0.661) and clinical utility. Hematological analyses indicated that granulocyte count (GRAN) significantly mediated the relationship between SAD and KSD (P

Suggested Citation

  • Wei Song & Shugen Li & Guangchun Wang & Shang Gao, 2025. "Increased sagittal abdominal diameter is associated with a higher risk of kidney stones," PLOS ONE, Public Library of Science, vol. 20(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0317717
    DOI: 10.1371/journal.pone.0317717
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