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Height development and multiple bone health indicators in children aged 2–12 years with Duchenne muscular dystrophy (DMD)

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Listed:
  • Bingying Wang
  • Linyuhan Zhou
  • Shuangru Li
  • Huayan Xu
  • Yingkun Guo
  • Qin Hu
  • Min Huang
  • Dan Zhou
  • Xiaotang Cai
  • Qiu Wang
  • Xiaomei Sun

Abstract

Introduction: Short stature is a frequent complication of DMD, and its pathomechanisms and influencing factors are specific to this disease and the idiosyncratic treatment for DMD. Purpose: To establish the height growth curve of early DMD, and evaluate the potential influencing markers on height growth, provide further evidence for pathological mechanism, height growth management and bone health in DMD. Methods: A retrospective, cross-sectional study of 348 participants with DMD aged 2–12 years was conducted at West China Second Hospital of Sichuan University from January 2023 to October 2023. Results: The growth curve for 2–12 years old boys with DMD indicates a slower growth rate compared to the average population. At age two, children with DMD have a similar height to their peers, but gradually falls behind afterwards. Short stature was observed in children with DMD before and after GC exposure, and prolonged GC use exacerbated the retardation. BMI (β = -0.47, p = 0.007), BMD (β = -0.005, p = 0.014), β-CTX (β = 0.001, p = 0.002), delayed BA (β = 0.417, p

Suggested Citation

  • Bingying Wang & Linyuhan Zhou & Shuangru Li & Huayan Xu & Yingkun Guo & Qin Hu & Min Huang & Dan Zhou & Xiaotang Cai & Qiu Wang & Xiaomei Sun, 2025. "Height development and multiple bone health indicators in children aged 2–12 years with Duchenne muscular dystrophy (DMD)," PLOS ONE, Public Library of Science, vol. 20(1), pages 1-12, January.
    • Handle: RePEc:plo:pone00:0316938
    DOI: 10.1371/journal.pone.0316938
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