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Wearable devices may aid the recognition of fluctuation-related pain in Parkinson’s disease—An exploratory, cross-sectional analysis of two prospective observational studies

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  • Katarina Rukavina
  • Juliet Staunton
  • Pavlos Zinzalias
  • Magdalena Krbot Skoric
  • Kit Wu
  • Kirsty Bannister
  • Alexandra Rizos
  • K Ray Chaudhuri

Abstract

Fluctuation-related pain (FRP) affects more than one third of people with Parkinson’s disease (PwP, PD) and has a harmful effect on health-related quality of life (HRQoL), but often remains under-reported by patients and neglected by clinicians. The National Institute for Health and Care Excellence (NICE) recommends The Parkinson KinetiGraphTM (the PKGTM) for remote monitoring of motor symptoms. We investigated potential links between the PKGTM-obtained parameters and clinical rating scores for FRP in PwP in an exploratory, cross-sectional analysis of two prospective studies: “The Non-motor International Longitudinal, Real-Life Study in PD—NILS” and “An observational-based registry of baseline PKG™ in PD—PKGReg”. 63 PwP (41.3% female; age: 64.24±9.88 years; disease duration, DD: 6.83±5.63 years; Hoehn and Yahr Stage, H&Y: 2 (1–4); Levodopa Equivalent Daily Dose 535 (0–3230) mg) were included. PwP with FRP (n = 23) had longer DD (8.88 (1.29–19.05) vs. 3.16 (0.34–28.92), p = 0.001), higher severity of motor symptoms (H&Y 3 (1–4) vs. 2 (1–4), p = 0.015; SCOPA Motor total score 21.35±10.19 vs. 13.65±8.99, p = 0.003), more dyskinesia (SCOPA Motor Item 18 ≥1 60.9% vs. 7.5%, p

Suggested Citation

  • Katarina Rukavina & Juliet Staunton & Pavlos Zinzalias & Magdalena Krbot Skoric & Kit Wu & Kirsty Bannister & Alexandra Rizos & K Ray Chaudhuri, 2025. "Wearable devices may aid the recognition of fluctuation-related pain in Parkinson’s disease—An exploratory, cross-sectional analysis of two prospective observational studies," PLOS ONE, Public Library of Science, vol. 20(1), pages 1-16, January.
    • Handle: RePEc:plo:pone00:0316563
    DOI: 10.1371/journal.pone.0316563
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    References listed on IDEAS

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    1. Malcolm K Horne & Sarah McGregor & Filip Bergquist, 2015. "An Objective Fluctuation Score for Parkinson's Disease," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-11, April.
    2. Marcus Orzabal & Ramo Naidu & Kasra Amirdelfan & Alireza Akhbardeh, 2022. "A Forehead Wearable Sensor for the Objective Measurement of Chronic Pain," IJERPH, MDPI, vol. 19(24), pages 1-11, December.
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