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Prevalence of prolonged transitional neonatal hypoglycemia and associated factors in Ethiopia: A systematic review and meta-analysis

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  • Solomon Demis Kebede
  • Amare Kassaw
  • Tigabu Munye Aytenew
  • Kindu Agmas
  • Demewoz Kefale

Abstract

Introduction: Most neonates experience transient hypoglycemia, which typically responds well to treatment and is associated with a favorable prognosis. However, hypoglycemia persisting beyond 48 hours, termed prolonged transitional Neonatal hypoglycemia (PTNHG), can result in abrupt neuronal injury and long-term neurodevelopmental impairments. Identifying its prevalence and associated risk factors is critical to inform clinical practices and improve neonatal outcomes. Methods: A weighted inverse-variance random-effects model was employed for the analysis. Heterogeneity among the studies was assessed using a forest plot, I2 statistics, and Egger’s test. Data extraction was conducted from May 20 to May 27, 2023, for studies published since 2020. A random blood sugar (RBS) concentration of 400 and ≤400, at 18% (95% CI: 15–22) and 21% (95% CI: 17–26), respectively. Similarly, prevalence estimates were comparable when using RBS thresholds of

Suggested Citation

  • Solomon Demis Kebede & Amare Kassaw & Tigabu Munye Aytenew & Kindu Agmas & Demewoz Kefale, 2025. "Prevalence of prolonged transitional neonatal hypoglycemia and associated factors in Ethiopia: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0316464
    DOI: 10.1371/journal.pone.0316464
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