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Association between vitamin D receptor gene polymorphism and essential hypertension: An updated systematic review, meta-analysis, and meta-regression

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  • Iwan Dakota
  • Muhamad Fajri Adda’i
  • Rido Maulana
  • Ignatius Ivan
  • Renan Sukmawan
  • Bambang Widyantoro

Abstract

The association between Vitamin D Receptor (VDR) gene polymorphisms and essential hypertension (EH) remains controversial. We searched databases (Cochrane Library, EBSCO, EMBASE, LILACS, ProQuest, PubMed, Science Direct, Springer) for studies on VDR gene polymorphisms and EH until May 30, 2024, following PRISMA guidelines. RevMan 5.4.1 provided pooled odds ratio (OR) under Hardy-Weinberg Equilibrium based on allele, additive, dominant, and recessive genetic models. Meta-regression was performed using Comprehensive Meta Analysis V3. Twenty-two studies from thirteen countries were analyzed. The recessive model suggested lower EH risk in individuals with the recessive allele (bb) of BsmI (OR: 0.81; 95%CI, 0.69 to 0.94, p = 0.007; I2 = 35%, p = 0.13). No significant associations were found for FokI, ApaI, and TaqI polymorphisms. Methodological quality significantly influenced EH risk associated with the FokI polymorphism across allele, additive, and dominant models (All p

Suggested Citation

  • Iwan Dakota & Muhamad Fajri Adda’i & Rido Maulana & Ignatius Ivan & Renan Sukmawan & Bambang Widyantoro, 2024. "Association between vitamin D receptor gene polymorphism and essential hypertension: An updated systematic review, meta-analysis, and meta-regression," PLOS ONE, Public Library of Science, vol. 19(12), pages 1-25, December.
    • Handle: RePEc:plo:pone00:0314886
    DOI: 10.1371/journal.pone.0314886
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    1. Denio A Ridjab & Ignatius Ivan & Fanny Budiman & Riki Tenggara, 2022. "Evaluation of subclinical ventricular systolic dysfunction assessed using global longitudinal strain in liver cirrhosis: A systematic review, meta-analysis, and meta-regression," PLOS ONE, Public Library of Science, vol. 17(6), pages 1-24, June.
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