IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0312751.html
   My bibliography  Save this article

Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis

Author

Listed:
  • Nader Muthanna
  • Xiaoyue Guan
  • Fouad Alzahrani
  • Badr Sultan Saif
  • Abdelrahman Seyam
  • Ahmed Alsalman
  • Ahmed Es Alajami
  • Ang Li

Abstract

Introduction: Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evaluate the impact of regenerative procedures on the healing process following SRCT. Methods: A comprehensive search of PubMed, Embase, Scopus, Cochrane, and the Web of Science found Randomized Controlled Trials (RCTs) published until February 25, 2024. Manual searches were also conducted. Our main outcome was SRCT success or failure after GTR procedures. The Risk Ratio (RR) and failure rate meta-analysis used a fixed effects model with a 95% confidence interval (CI). Subgroup analyses were conducted based on the use of different GTR procedures for varying lesion types in SRCT. Results: Out of 1,605 records, 16 studies with 690 lesions were included. Overall, GTR procedures significantly improved healing after SRCT in both 2D (RR: 0.50; 95% CI, 0.34–0.73; P

Suggested Citation

  • Nader Muthanna & Xiaoyue Guan & Fouad Alzahrani & Badr Sultan Saif & Abdelrahman Seyam & Ahmed Alsalman & Ahmed Es Alajami & Ang Li, 2025. "Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(1), pages 1-19, January.
    • Handle: RePEc:plo:pone00:0312751
    DOI: 10.1371/journal.pone.0312751
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0312751
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0312751&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0312751?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0312751. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.