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Prognostic value of the systemic immune-inflammation index in lung cancer patients receiving immune checkpoint inhibitors: A meta-analysis

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  • Yanhui Yang
  • Ji Li
  • Yi Wang
  • Lei Luo
  • Yi Yao
  • Xiaoyang Xie

Abstract

Purpose: To explore the association between the systemic immune-inflammation index (SII) score and prognosis in immune checkpoint inhibitor (ICI)-treated patients with lung cancer. Methods: PubMed, EMBASE, Web of Science, and CNKI databases were searched up to August 1, 2024. Progression-free survival (PFS) and overall survival (OS) were the primary outcomes queried. Hazard ratios (HRs) and 95% confidence intervals (CIs) were combined, and subgroup analysis was based on pathological type [non-small cell lung cancer (NSCLC) vs. small-cell lung cancer (SCLC)], lines of ICIs (first-line vs. second- or further-line), and combinations of other therapies (yes vs. no). Results: Twenty retrospective studies with 2424 participants were included. The pooled results demonstrated that an elevated SII was associated with poorer PFS (HR = 1.82, 95% CI: 1.49–2.21; P

Suggested Citation

  • Yanhui Yang & Ji Li & Yi Wang & Lei Luo & Yi Yao & Xiaoyang Xie, 2024. "Prognostic value of the systemic immune-inflammation index in lung cancer patients receiving immune checkpoint inhibitors: A meta-analysis," PLOS ONE, Public Library of Science, vol. 19(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0312605
    DOI: 10.1371/journal.pone.0312605
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