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Activity of glucose-6-phosphate dehydrogenease and its correlation with inflammatory factors in diabetic retinopathy

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Listed:
  • Dan Liu
  • Chuchu Cheng
  • Lan Zhou
  • Qiqiao Zeng
  • Tao Zi
  • Gongyi Chen
  • Hongyan Sun
  • Cunzi Li
  • Jun Wang
  • Ming-Ming Yang

Abstract

Purpose: This study aims to explore glucose-6-phosphate dehydrogenase (G6PD) activity in diabetic retinopathy (DR) and its correlation with inflammatory factors, elucidating the regulatory role of G6PD in DR pathology. Methods: A total of 151 T2DM patients were divided into three groups: diabetes without retinopathy (DNR, n = 59), non-proliferative retinopathy (NPDR, n = 46) and proliferative retinopathy (PDR, n = 49). Plasma G6PD activity was measured by a Randox G6PD kit and compared between these groups. Then the G6PD activity was correlated with inflammatory cytokines and metabolic parameters in these patients. A STZ-induced diabetic rat model was established, G6PD activity was validated by western blot and immunofluorescence staining in the retina of this model. Results: Plasma G6PD activity decreased in the order of DNR, NPDR and PDR groups (P

Suggested Citation

  • Dan Liu & Chuchu Cheng & Lan Zhou & Qiqiao Zeng & Tao Zi & Gongyi Chen & Hongyan Sun & Cunzi Li & Jun Wang & Ming-Ming Yang, 2024. "Activity of glucose-6-phosphate dehydrogenease and its correlation with inflammatory factors in diabetic retinopathy," PLOS ONE, Public Library of Science, vol. 19(12), pages 1-11, December.
    • Handle: RePEc:plo:pone00:0312452
    DOI: 10.1371/journal.pone.0312452
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