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Prediabetes increases the risk of pancreatic cancer: A meta-analysis of longitudinal observational studies

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  • Xuefang Huang
  • Huan Li
  • Lisha Zhao
  • Lingli Xu
  • Hui Long

Abstract

Background: Glycemic disorder is closely related to the risk of pancreatic cancer, but previous studies focused on the influence of diabetes. The aim of this meta-analysis was to investigate the influence of prediabetes, an intermediate state between normoglycemia and diabetes, on the risk of pancreatic cancer. Methods: Relevant longitudinal observational studies were identified through a search of Medline, Embase, and Web of Science databases. To minimize the influence of between-study heterogeneity, a randomized-effects model was used to pool the results. Results: Nine cohort studies including 26,444,624 subjects were available for the meta-analysis. Among them, 2,052,986 (7.8%) had prediabetes at baseline, and the participants were followed for a mean duration of 5.9 years. It was found that, compared to people with normoglycemia, those with prediabetes had a higher incidence of pancreatic cancer (risk ratio [RR]: 1.42, 95% confidence interval: 1.36 to 1.49, p 0.05). Conclusions: Prediabetes may be associated with an increased risk of pancreatic cancer compared to normoglycemia.

Suggested Citation

  • Xuefang Huang & Huan Li & Lisha Zhao & Lingli Xu & Hui Long, 2024. "Prediabetes increases the risk of pancreatic cancer: A meta-analysis of longitudinal observational studies," PLOS ONE, Public Library of Science, vol. 19(10), pages 1-16, October.
    • Handle: RePEc:plo:pone00:0311911
    DOI: 10.1371/journal.pone.0311911
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