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Association between triglyceride and depression: A systematic review and meta-analysis

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  • Di-Ru Xu
  • Xi Gao
  • Li-Bo Zhao
  • Shu-Dong Liu
  • Ge Tang
  • Chan-Juan Zhou
  • Yu Chen

Abstract

Depression is accompanied by dyslipidemia, which may increase the risk of stroke and coronary heart disease. This study sought to quantitatively summarize the clinical data comparing peripheral blood triglyceride (TG) concentrations between patients with major depressive disorder (MDD) and healthy controls (HCs). Studies were searched in PubMed, EMBASE, PsycINFO, and Cochrane Databases up to March 2023. We also reviewed the reference lists of obtained articles. Mean (±SD) for TG concentrations were extracted, combined quantitatively using random-effects meta-analysis, and summarized as a standardized mean difference (SMD). Subgroup analysis and meta-regression was performed to explore the resource of heterogeneity. Thirty-eight studies measuring the concentrations of peripheral blood TG in 2604 patients with MDD and 3272 HCs were included. Meta-analysis results indicated that TG levels were significant higher in patients with MDD than in HCs (SMD = 0.31, 95% confidence interval [CI]: 0.16 to 0.46, Z46 = 4.05, p

Suggested Citation

  • Di-Ru Xu & Xi Gao & Li-Bo Zhao & Shu-Dong Liu & Ge Tang & Chan-Juan Zhou & Yu Chen, 2024. "Association between triglyceride and depression: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 19(10), pages 1-15, October.
    • Handle: RePEc:plo:pone00:0311625
    DOI: 10.1371/journal.pone.0311625
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