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Ultrasound renal denervation in hypertensive patients: A systematic review and meta-analysis

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Listed:
  • Roy Novri Ramadhan
  • Derren David Christian Homenta Rampengan
  • Felicia Angelica Gunawan
  • Nathania
  • Sebastian Emmanuel Willyanto
  • Hiroyuki Yamada
  • Mochammad Thaha
  • Satriyo Dwi Suryantoro
  • Maulana Antiyan Empitu

Abstract

Introduction: Hypertension is the leading noncommunicable disease case affecting 1.28 billion individuals worldwide, with most cases located in low- and middle-income countries. While there are numerous techniques for treating mild to moderate hypertension, properly controlling severe or resistant hypertension poses substantial challenges. Ultrasound-based renal denervation (uRDN) has emerged as a promising non-pharmacological approach. This study aims to investigate the safety and efficacy of uRDN in hypertensive patients. Methods: The literature search across PubMed, ScienceDirect, BMJ Journals, ProQuest, and Springer databases yielded 419 articles. A total of 395 articles were filtered, leading to 24 articles assessed for eligibility and overall analysis, which resulted in eight included studies for quantitative synthesis. Quality appraisal used RoB 2.0, while meta-analysis used RevMan 5.4. Results: Our analysis results indicated significant improvements in 24-hour, daytime, and home ambulatory blood pressure measurements, favoring the uRDN over control. The mean difference (MD) for 24-hour measurements was -0.84 mmHg [95% CI -1.14, -0.55; p

Suggested Citation

  • Roy Novri Ramadhan & Derren David Christian Homenta Rampengan & Felicia Angelica Gunawan & Nathania & Sebastian Emmanuel Willyanto & Hiroyuki Yamada & Mochammad Thaha & Satriyo Dwi Suryantoro & Maulan, 2025. "Ultrasound renal denervation in hypertensive patients: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 20(1), pages 1-16, January.
    • Handle: RePEc:plo:pone00:0311191
    DOI: 10.1371/journal.pone.0311191
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    References listed on IDEAS

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    1. Daniel Gladwell & Thea Henry & Mark Cook & Ron Akehurst, 2014. "Cost Effectiveness of Renal Denervation Therapy for the Treatment of Resistant Hypertension in the UK," Applied Health Economics and Health Policy, Springer, vol. 12(6), pages 611-622, December.
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