Diagnostic of fatty liver using radiomics and deep learning models on non-contrast abdominal CT

Purpose: This study aims to explore the potential of non-contrast abdominal CT radiomics and deep learning models in accurately diagnosing fatty liver. Materials and methods: The study retrospectively enrolled 840 individuals who underwent non-contrast abdominal CT and quantitative CT (QCT) examinations at the First Affiliated Hospital of Zhengzhou University from July 2022 to May 2023. Subsequently, these participants were divided into a training set (n = 539) and a testing set (n = 301) in a 9:5 ratio. The liver fat content measured by experienced radiologists using QCT technology served as the reference standard. The liver images from the non-contrast abdominal CT scans were then segmented as regions of interest (ROI) from which radiomics features were extracted. Two-dimensional (2D) and three-dimensional (3D) radiomics models, as well as 2D and 3D deep learning models, were developed, and machine learning models based on clinical data were constructed for the four-category diagnosis of fatty liver. The characteristic curves for each model were plotted, and area under the receiver operating characteristic curve (AUC) were calculated to assess their efficacy in the classification and diagnosis of fatty liver. Results: A total of 840 participants were included (mean age 49.1 years ± 11.5 years [SD]; 581 males), of whom 610 (73%) had fatty liver. Among the patients with fatty liver, there were 302 with mild fatty liver (CT fat fraction of 5%–14%), 155 with moderate fatty liver (CT fat fraction of 14%–28%), and 153 with severe fatty liver (CT fat fraction >28%). Among all models used for diagnosing fatty liver, the 2D radiomics model based on the random forest algorithm achieved the highest AUC (0.973), while the 2D radiomics model based on the Bagging decision tree algorithm showed the highest sensitivity (0.873), specificity (0.939), accuracy (0.864), precision (0.880), and F1 score (0.876). Conclusion: A systematic comparison was conducted on the performance of 2D and 3D radiomics models, as well as deep learning models, in the diagnosis of four-category fatty liver. This comprehensive model comparison provides a broader perspective for determining the optimal model for liver fat diagnosis. It was found that the 2D radiomics models based on the random forest and Bagging decision tree algorithms show high consistency with the QCT-based classification diagnosis of fatty liver used by experienced radiologists.